Experience the warmth of Southern comfort with this Five-Layer Beef Casserole—a hearty, flavor-packed dish steeped in tradition. With tender ground beef, melty cheese, and a golden biscuit crust, this recipe brings warmth to any table. Whether you’re feeding a hungry family or planning a cozy night in, this casserole transforms simple ingredients into something unforgettable.
A Southern Tradition on Your Table
Inspired by generations of home cooks, this casserole captures the spirit of Southern hospitality. It’s a dish rooted in family gatherings, community potlucks, and the kind of kitchen love that’s passed down through time. Best of all? It’s easy, adaptable, and always satisfying.
Ingredients
Main Ingredients
- Ground beef – as needed
- 1 onion, chopped
- 1 green bell pepper, diced
- 1 cup tomato sauce
- 1 teaspoon garlic powder
- Salt and pepper to taste
- 1 cup shredded cheddar cheese
- 1 cup shredded mozzarella cheese
Batter Layer
- 1 cup biscuit baking mix
- ½ cup milk
- 2 eggs
Customizations:
- Want a kick of spice? Add jalapeños or red pepper flakes.
- Going vegetarian? Use tofu crumbles or your favorite plant-based meat substitute.
- Switch up the cheese for a sharper or creamier finish.
Instructions
Step 1: Preheat and Prepare
Preheat your oven to 375°F (190°C). Lightly grease a 9×13-inch baking dish or similar casserole pan.
Step 2: Cook the Beef Mixture
In a large skillet over medium heat, brown the ground beef with chopped onions and green bell pepper. Cook until the beef is no longer pink and vegetables are softened. Drain excess fat.
Stir in the tomato sauce, garlic powder, salt, and pepper. Allow it to simmer for 10 minutes so the flavors can blend together beautifully.
Step 3: Mix the Batter
In a mixing bowl, combine the biscuit baking mix, milk, and eggs. Whisk until a thick, pourable batter forms.
Step 4: Layer the Casserole
Evenly spread half of the batter across the bottom of the prepared baking dish. Top with half of the beef mixture, then sprinkle with half of each cheese.
Repeat the layering with the remaining batter, beef mixture, and cheese, finishing with a generous layer of cheese on top.
Step 5: Bake
Bake uncovered for 25–30 minutes, or until the top is golden brown and the casserole is bubbling around the edges.
Step 6: Serve and Enjoy
Let the casserole cool for 5–10 minutes to set. Slice and serve warm for a comforting, cheesy Southern feast.
Pro Tips
- For extra crispiness, bake uncovered during the last 5 minutes.
- Let it rest before slicing if you prefer a softer, more cohesive texture.
- Mix up the cheeses—try pepper jack, Monterey Jack, or smoked gouda for a twist.